|
Product |
14-3-3 gamma |
Antigen |
Synthetic peptide derived from the N-terminal region of the human 14-3-3 gamma protein. |
Antigen
Species |
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Catalog
Number |
0014-07D |
Quantity |
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Price |
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 |
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Reactivity
Against |
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Applications |
Suitable for use in ELISA and Western Blot. Other applications have not been tested. |
Host |
Mouse |
Conjugate |
|
Type
of Ab |
Monoclonal |
Ab
Isotype |
IgG2a.k |
Storage |
May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing. aliquot and add glycerol (40-50%). Freeze at -20°C or colder. Aliquots are stable for at least 24 months at -20°C. For maximum recovery of product. centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. |
Description |
Members of the 14-3-3 protein family play an important role in signal transduction leading to mitosis and cellular proliferation. The 14-3-3 family of proteins mediates signal transduction by binding to phosphoserine-containing proteins. Immunohistochemical analyses showed that the 14-3-3 protein is located exclusively in the cytoplasm of neurons in the cerebral cortex and is axonally transported to the nerve terminals. Electrophoresis and chromatography demonstrated that the 14-3-3 protein exists in at least 8 distinct forms: alpha. beta. gamma. delta. epsilon. zeta. eta. and theta. The human 14-3-3 gamma gene (HGMW-approved symbol YWHAG) is highly expressed in brain. skeletal muscle. and heart. In Alzheimers disease and Down syndrome. the level of 14-3-3 gamma in brain increases significantly. |
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External Information for
14-3-3 gamma |
|
EMBL
Harvester |
Search
Bioinformatic Harvester for 14-3-3 gamma
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Pubmed |
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Medline |
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OMIM |
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Genecard |
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