|
Product |
4E Binding Protein 1 (4E-BP1) |
Antigen |
Synthetic peptide (KLH coupled) corresponding to residues surrounding Ser112 of human 4E-BP1. |
Antigen
Species |
Human |
Catalog
Number |
0004-18 |
Quantity |
100µl |
Price |
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 |
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Reactivity
Against |
|
Applications |
Suitable for use in ELISA. Western Blot. Immunoprecipitation. Immunohistochemistry. Immunocytochemistry and Flow Cytometry. Other applications not tested. |
Host |
Rabbit |
Conjugate |
|
Type
of Ab |
Polyclonal |
Ab
Isotype |
IgG |
Storage |
May be stored at 4°C for short-term only. For long-term storage. store at -20°C. Aliquots are stable for at least 24 months at -20°C. For maximum recovery of product. centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. |
Description |
4E-BP1 (also known as PHAS-1) normally binds eIF4E. inhibiting cap-dependent translation. Hyperphosphorylation of 4E-BP1 disrupts this binding. activating cap-dependent translation (1). The PI3 kinase/Akt pathway and FRAP/mTOR kinase regulate 4E-BP1 (2.3). 4E-BP1 is phosphorylated in vivo on multiple residues (4); phosphorylation by FRAP/mTOR on Thr37 and Thr46 of human 4E-BP1 may prime it for subsequent phosphorylation at sites including Ser65 and Thr70 (5). |
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External Information for
4E Binding Protein 1 (4E-BP1) |
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