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Product |
A-20 Zinc Finger Protein |
Antigen |
Recombinant fusion protein of full length human A20. |
Antigen
Species |
Human |
Catalog
Number |
A0000-10 |
Quantity |
100µg |
Price |
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 |
 |
Reactivity
Against |
Human |
Applications |
Western Blot. Whole cell lysate from Daudi cells can be used as positive control and an approximately 70kD band is detected. |
Host |
Mouse |
Conjugate |
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Type
of Ab |
|
Ab
Isotype |
IgG1 |
Storage |
May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing. aliquot and add glycerol (40-50%). Freeze at -20°C or colder. Aliquots are stable for at least 24 months at -20°C. For maximum recovery of product. centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. |
Description |
NF-kB (nuclear factor kB) regulates the expression of a large number of genes that play critical roles in apoptosis. viral replication. tumorigenesis. various autoimmune diseases and inflammation (1). The zinc finger protein A20 (2) is a tumor necrosis factor and interleukin 1 (IL-1)-inducible protein that negatively regulates NF-kB gene expression. A20 inhibits NF-kB dependent gene expression by interfering with a novel TNF-induced and RIP- or TRAF2-mediated pathway that is different from the NIK-IkB kinase pathway (3). A20 is expressed at low levels in most organs. the highest expression levels being in lymphoid tissues. (4). Recently. it has been shown that A20 protein level is increased in lung neutrophils after endotoxemia (5). |
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External Information for
A-20 Zinc Finger Protein |
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